Bismuth subsalicylate creates a protective coating for the esophagus and stomach lining. It exerts an anti-diarrheal effect by encouraging the absorption of fluids and electrolytes in the intestines and inhibits prostaglandins responsible for inflammation. Additionally, it binds and neutralizes toxins from harmful bacteria like E. coli, and fights H. pylori infection in the gastrointestinal tract.
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It is believed to work by several methods. First, it increases mucus glycoprotein secretion and may also bind to the gastric mucus layer to act as a diffusion barrier to HCl. It is also known to have a cytoprotective effect and enhances mucosal secretion of prostaglandins and bicarbonate.
Black tongue, Dark colored stool, Nausea, Vomiting, Bone toxicity, Joint toxicity
Antacid Action: Bismuth Subsalicylate coats ulcer surfaces, protecting them from acid and pepsin. It stimulates the secretion of mucus and bicarbonate and reacts with hydrochloric acid (HCl) to produce bismuth oxychloride and salicylic acid, thus reducing stomach acidity.
Anti-Diarrheal Action: Peptofit 17.5mg/ml Suspension encourages the absorption of water and electrolytes across the intestinal wall. It also binds to toxins produced by E. coli and disrupts H. pylori cells, preventing their adhesion to the intestinal wall.
Anti-Inflammatory Action: Once hydrolyzed to salicylic acid, Peptofit 17.5mg/ml Suspension inhibits prostaglandin synthesis, which reduces inflammation and coats irritated tissue, helping to prevent fluid expulsion.
Since Peptofit 17.5mg/ml Suspension contains salicylates, it should be used cautiously in patients taking:
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